Experimental pathology

Experimental Pathology of Ornithobilharzia turkestanicum in Sheep.

Clinical & Experimental Pathology

In humans, HHcy causes various symptoms such as mental retardation, epilepsy, epileptic seizures and atherosclerosis, whose pathology is not fully understood. Pro-inflammatory mediators released by activated microglia secrete various neurotoxic factors such as NO and ROS, which contribute to neuronal degeneration in neurodegenerative diseases [1,2]. Within this context, HHcy proved to cause neu...

Experimental and Molecular Pathology

Gulf War Syndrome (GWS) is a multisystemic illness afflicting many Gulf War-era veterans. The molecular pathological basis for GWS has not been established. We sought to determine whether the presence of antibodies to squalene correlates with the presence of signs and symptoms of GWS. Participants in this blinded cohort study were individuals immunized for service in Desert Shield/Desert Storm ...

Experimental and Molecular Pathology

The development and progression of atherosclerotic lesions in Watanabe heritable hyperlipidemic rabbits is associated with increases in inducible nitric oxide synthase (NOS2) and endothelin-1 (ET-1) immunoreactivity. In contrast, there is a reduction of immunoreactivity for neuronal NOS (NOS1) in aortic endothelial cells, but no change in endothelial NOS (NOS3) immunoreactivity. However, subend...

Experimental and Molecular Pathology

Infection with mouse hepatitis virus (MHV) strain A59 produces acute hepatitis, encephalitis, and chronic demyelination in mice. However, little is known about a closely related strain, MHV-2, which is only weakly neurotropic. To better understand the molecular basis of neurotropism of MHVs, we compared the pathogenesis and genomic sequence of MHV-2 with that of MHV-A59. Intracerebral injection...